LC8 Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Binds and inhibits the catalytic activity of neuronal nitric oxide synthase. Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1. Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity. Belongs to the dynein light chain family. Ubiquitous. Note: This description may include information from UniProtKB.
Protein type: Microtubule-binding; Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 5|5 F
Cellular Component:  axon cytoplasm; centrosome; cytoplasm; cytoplasmic dynein complex; cytoskeleton; cytosol; dynein complex; kinetochore; membrane; microtubule; microtubule associated complex; mitotic spindle; nucleus; secretory granule
Molecular Function:  dynein intermediate chain binding; dynein light intermediate chain binding; enzyme binding; enzyme inhibitor activity; motor activity; nitric-oxide synthase regulator activity; protein binding; protein C-terminus binding; protein domain specific binding; protein heterodimerization activity; protein homodimerization activity; scaffold protein binding
Biological Process:  apoptotic process; intraciliary retrograde transport; microtubule-based process; motile cilium assembly; negative regulation of nitric oxide biosynthetic process; negative regulation of phosphorylation; positive regulation of ATP-dependent microtubule motor activity, plus-end-directed; positive regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of non-motile cilium assembly
Reference #:  P63168 (UniProtKB)
Alt. Names/Synonyms: 8 kDa dynein light chain; 8kD LC; 8kDa LC; DLC; Dlc1; DLC8; Dncl; Dncl1; Dnclc1; DYL1; Dynein light chain 1, cytoplasmic; Dynein light chain LC8-type 1; dynein, cytoplasmic, light chain 1; dynein, cytoplasmic, light peptide; Dynll1; LC8; mPIN; OTTMUSP00000015546; OTTMUSP00000015547; PIN; Protein inhibitor of neuronal nitric oxide synthase; protein inhibitor of nitric oxide synthase
Gene Symbols: Dynll1
Molecular weight: 10,366 Da
Basal Isoelectric point: 6.89  Predict pI for various phosphorylation states
CST Pathways:  Mitochondrial Control of Apoptosis
Select Structure to View Below

LC8

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene