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LC8
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Binds and inhibits the catalytic activity of neuronal nitric oxide synthase. Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1. Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity. Belongs to the dynein light chain family. Ubiquitous. Note: This description may include information from UniProtKB.
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| Protein type: Microtubule-binding; Motility/polarity/chemotaxis; Motor |
| Chromosomal Location of mouse Ortholog: 5|5 F |
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Cellular Component:
axon cytoplasm; centrosome; COP9 signalosome; cytoplasm; cytoplasmic dynein complex; cytoskeleton; cytosol; dynein complex; kinetochore; membrane; microtubule; microtubule associated complex; mitochondrion; mitotic spindle; nucleus; secretory granule
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Molecular Function:
dynein intermediate chain binding; enzyme binding; enzyme inhibitor activity; identical protein binding; nitric-oxide synthase regulator activity; protein binding; protein domain specific binding; protein-containing complex binding; scaffold protein binding
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Biological Process:
apoptotic process; intraciliary retrograde transport; microtubule-based process; mitocytosis; motile cilium assembly; negative regulation of nitric oxide biosynthetic process; negative regulation of phosphorylation; positive regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of non-motile cilium assembly; regulation of mitochondrial membrane potential
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Reference #:
P63168
(UniProtKB)
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Alt. Names/Synonyms: 8 kDa dynein light chain; 8kD LC; 8kDa LC; DLC; Dlc1; DLC8; Dncl; Dncl1; Dnclc1; DYL1; Dynein light chain 1, cytoplasmic; Dynein light chain LC8-type 1; dynein, cytoplasmic, light chain 1; dynein, cytoplasmic, light peptide; Dynll1; LC8; mPIN; OTTMUSP00000015546; OTTMUSP00000015547; PIN; Protein inhibitor of neuronal nitric oxide synthase; protein inhibitor of nitric oxide synthase
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Gene Symbols: Dynll1
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Molecular weight:
10,366 Da
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Basal Isoelectric point:
6.89
Predict pI for various phosphorylation states
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CST Pathways:
Mitochondrial Control of Apoptosis
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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