NCKIPSD Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo. In vitro, stimulates N-WASP- induced ARP2/3 complex activation in the absence of CDC42. May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis. A chromosomal aberration involving NCKIPSD/AF3p21 is found in therapy-related leukemia. Translocation t(3;11)(p21;q23) with MLL. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis; Oncoprotein
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component:  cytosol; intermediate filament
Molecular Function:  cytoskeletal protein binding; protein binding; SH3 domain binding
Biological Process:  cytoskeleton organization; Fc-gamma receptor signaling pathway involved in phagocytosis; positive regulation of neuron projection development
Reference #:  Q9NZQ3 (UniProtKB)
Alt. Names/Synonyms: 54 kDa VacA-interacting protein; 90 kDa SH3 protein interacting with Nck; AF3P21; dia interacting protein; Dia-interacting protein 1; diaphanous protein interacting protein; Diaphanous protein-interacting protein; DIP; DIP-1; DIP1; MGC23891; NCK interacting protein with SH3 domain; NCK-interacting protein with SH3 domain; NCKIPSD; ORF1; SH3 adapter protein SPIN90; SH3 protein interacting with Nck, 90 kDa; SPIN90; SPN90; VIP54; WASLBP; WISH
Gene Symbols: NCKIPSD
Molecular weight: 78,960 Da
Basal Isoelectric point: 5.94  Predict pI for various phosphorylation states
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NCKIPSD

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein