ANK1 Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. Isoform Mu17: Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. Isoform Mu17, isoform Mu18, isoform Mu19 and isoform Mu20 are expressed in skeletal muscle. Isoform Br21 is expressed in brain. 17 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Cell development/differentiation; Endoplasmic reticulum; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 8p11.21
Cellular Component:  axolemma; basolateral plasma membrane; cytoplasmic side of plasma membrane; cytoskeleton; cytosol; M band; nucleus; plasma membrane; postsynaptic membrane; sarcolemma; sarcoplasmic reticulum; spectrin-associated cytoskeleton; Z disc
Molecular Function:  ATPase binding; cytoskeletal adaptor activity; enzyme binding; protein binding; protein phosphatase binding; spectrin binding; structural constituent of cytoskeleton; structural molecule activity
Biological Process:  cytoskeleton organization; ER to Golgi vesicle-mediated transport; exocytosis; maintenance of epithelial cell apical/basal polarity; positive regulation of organelle organization; protein localization to plasma membrane; signal transduction
Disease: Spherocytosis, Type 1
Reference #:  P16157 (UniProtKB)
Alt. Names/Synonyms: ANK; ANK-1; ANK1; ankyrin 1; ankyrin 1, erythrocytic; Ankyrin-1; Ankyrin-R; Erythrocyte ankyrin; SPH1; SPH2
Gene Symbols: ANK1
Molecular weight: 206,265 Da
Basal Isoelectric point: 5.65  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein