TTYH2 Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction. May be involved in cell proliferation and cell aggregation. Belongs to the tweety family. Expressed at higher level in brain and testis and at lower levels in heart, ovary, spleen and peripheral blood leukocytes. Up-regulated in 13 of 16 renal cell carcinoma samples examined. Up-regulated in colon carcinoma. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, chloride; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel
Chromosomal Location of human Ortholog: 17q25.1
Cellular Component:  chloride channel complex; plasma membrane
Molecular Function:  intracellular calcium activated chloride channel activity; protein binding; volume-sensitive chloride channel activity
Biological Process:  chloride transmembrane transport
Reference #:  Q9BSA4 (UniProtKB)
Alt. Names/Synonyms: C17orf29; hTTY2; MGC126172; MGC4837; Protein tweety homolog 2; TTYH2; tweety family member 2; tweety homolog 2; tweety homolog 2 (Drosophila)
Gene Symbols: TTYH2
Molecular weight: 58,772 Da
Basal Isoelectric point: 5.48  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein