|
TTYH2
Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction. May be involved in cell proliferation and cell aggregation. Belongs to the tweety family. Expressed at higher level in brain and testis and at lower levels in heart, ovary, spleen and peripheral blood leukocytes. Up-regulated in 13 of 16 renal cell carcinoma samples examined. Up-regulated in colon carcinoma. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Channel, chloride; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel |
| Chromosomal Location of human Ortholog: 17q25.1 |
|
Cellular Component:
chloride channel complex; plasma membrane
|
|
Molecular Function:
intracellular calcium activated chloride channel activity; protein binding; volume-sensitive chloride channel activity
|
|
Biological Process:
chloride transmembrane transport
|
|
Reference #:
Q9BSA4
(UniProtKB)
|
|
Alt. Names/Synonyms: C17orf29; hTTY2; MGC126172; MGC4837; Protein tweety homolog 2; TTYH2; tweety family member 2; tweety homolog 2; tweety homolog 2 (Drosophila)
|
|
Gene Symbols: TTYH2
|
|
Molecular weight:
58,772 Da
|
|
Basal Isoelectric point:
5.48
Predict pI for various phosphorylation states
|
