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eIF4G
Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Belongs to the eukaryotic initiation factor 4G family. 8 alternative splicing and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: RNA-binding; Translation; Translation initiation |
| Chromosomal Location of rat Ortholog: 11q23 |
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Cellular Component:
cytoplasm; cytoplasmic stress granule; cytosol; eukaryotic translation initiation factor 4F complex; nucleus; polysome; postsynapse
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Molecular Function:
ATP binding; eukaryotic initiation factor 4E binding; identical protein binding; mRNA binding; translation factor activity, RNA binding; translation initiation factor activity
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Biological Process:
behavioral fear response; cellular response to nutrient levels; energy homeostasis; lung development; macromolecule biosynthetic process; miRNA-mediated gene silencing by inhibition of translation; negative regulation of autophagy; negative regulation of peptidyl-threonine phosphorylation; neuron differentiation; positive regulation of cell growth; positive regulation of eukaryotic translation initiation factor 4F complex assembly; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of mRNA cap binding; positive regulation of neuron differentiation; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein metabolic process; positive regulation of translation in response to endoplasmic reticulum stress; regulation of polysome binding; regulation of presynapse assembly; regulation of translational initiation; response to ethanol; translation; translational initiation
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Reference #:
D3ZU13
(UniProtKB)
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Alt. Names/Synonyms: eIF4G; Eif4g1; Eukaryotic translation initiation factor 4 gamma, 1
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Gene Symbols: Eif4g1
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Molecular weight:
175,705 Da
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Basal Isoelectric point:
5.29
Predict pI for various phosphorylation states
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CST Pathways:
Translation: eIF4E and p70S6K
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Translational Control
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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