eIF4G Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. Interacts with eIF3, mutually exclusive with EIF4A1 or EIFA2, EIF4E and through its N-terminus with PAPBC1. Interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate EIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. EIF4G1/EIF4G3 interacts with PABPC1 to bring about circularization of the mRNA. Rapamycin can attenuate insulin stimulation mediated by FKBPs. Interacts with EIF4E3. Interacts with CIRBP and MIF4GD. Interacts with rotavirus A NSP3; in this interaction, NSP3 takes the place of PABPC1 thereby inducing shutoff of host protein synthesis. Interacts with RBM4. Belongs to the eIF4G family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: RNA-binding; Translation; Translation initiation
Chromosomal Location of Human Ortholog: 11q23
Cellular Component:  cytoplasm; cytosol; eukaryotic translation initiation factor 4F complex; nucleus; polysome; postsynapse
Molecular Function:  ATP binding; eukaryotic initiation factor 4E binding; identical protein binding; mRNA binding; translation factor activity, RNA binding; translation initiation factor activity
Biological Process:  behavioral fear response; cellular macromolecule biosynthetic process; cellular response to nutrient levels; energy homeostasis; lung development; mitochondrion organization; negative regulation of autophagy; negative regulation of peptidyl-threonine phosphorylation; positive regulation of cell death; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of cellular protein metabolic process; positive regulation of eukaryotic translation initiation factor 4F complex assembly; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of miRNA mediated inhibition of translation; positive regulation of mRNA cap binding; positive regulation of neuron differentiation; positive regulation of peptidyl-serine phosphorylation; regulation of polysome binding; regulation of presynapse assembly; regulation of translational initiation; response to ethanol; translation; translational initiation
Reference #:  D3ZU13 (UniProtKB)
Alt. Names/Synonyms: Eif4g1; Eukaryotic translation initiation factor 4 gamma, 1
Gene Symbols: Eif4g1
Molecular weight: 175,705 Da
Basal Isoelectric point: 5.29  Predict pI for various phosphorylation states
CST Pathways:  Translation: eIF4E and p70S6K  |  Translational Control
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  Ensembl Protein