BTLA Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 3q13.2
Cellular Component:  integral component of plasma membrane; plasma membrane
Molecular Function:  protein binding; signaling receptor activity
Biological Process:  adaptive immune response; immune response-regulating cell surface receptor signaling pathway; T cell costimulation
Reference #:  Q7Z6A9 (UniProtKB)
Alt. Names/Synonyms: B and T lymphocyte associated; B and T lymphocyte attenuator; B- and T-lymphocyte attenuator; B- and T-lymphocyte-associated protein; BTLA; BTLA1; CD272; FLJ16065; MGC129743
Gene Symbols: BTLA
Molecular weight: 32,834 Da
Basal Isoelectric point: 6.09  Predict pI for various phosphorylation states
Select Structure to View Below

BTLA

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene