Pyk2 a nonreceptor tyrosine kinase of the Fak family. Predominantly expressed in the cells derived from hematopoietic lineages and in the central nervous system. Pyk2 is one of the signaling mediators for G-protein-coupled receptors. Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. It plays an important role in cell motility such as spreading and migration. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.2; Fak family; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group
Chromosomal Location of Human Ortholog: 8p21.2
Cellular Component:  apical dendrite; cell body; cell cortex; cytoplasm; cytoskeleton; cytosol; dendrite; extrinsic component of cytoplasmic side of plasma membrane; focal adhesion; glutamatergic synapse; growth cone; lamellipodium; membrane raft; neuronal cell body; NMDA selective glutamate receptor complex; nucleus; perinuclear region of cytoplasm; postsynaptic density
Molecular Function:  3-phosphoinositide-dependent protein kinase binding; ATP binding; calmodulin-dependent protein kinase activity; non-membrane spanning protein tyrosine kinase activity; protein binding; protein C-terminus binding; protein tyrosine kinase activity; protein-containing complex binding; ubiquitin protein ligase binding
Biological Process:  activation of GTPase activity; activation of Janus kinase activity; adaptive immune response; apoptotic process; blood vessel endothelial cell migration; bone resorption; cell surface receptor signaling pathway; cellular defense response; cellular response to fluid shear stress; cellular response to retinoic acid; chemokine-mediated signaling pathway; focal adhesion assembly; glial cell proliferation; integrin-mediated signaling pathway; interleukin-2-mediated signaling pathway; ionotropic glutamate receptor signaling pathway; long-term synaptic depression; long-term synaptic potentiation; MAPK cascade; marginal zone B cell differentiation; negative regulation of apoptotic process; negative regulation of bone mineralization; negative regulation of cell proliferation; negative regulation of muscle cell apoptotic process; negative regulation of myeloid cell differentiation; negative regulation of neuron apoptotic process; negative regulation of potassium ion transport; neuron projection development; oocyte maturation; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; positive regulation of actin filament polymerization; positive regulation of angiogenesis; positive regulation of B cell chemotaxis; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of cell-matrix adhesion; positive regulation of cytosolic calcium ion concentration; positive regulation of DNA biosynthetic process; positive regulation of endothelial cell migration; positive regulation of ERK1 and ERK2 cascade; positive regulation of excitatory postsynaptic potential; positive regulation of JNK cascade; positive regulation of JUN kinase activity; positive regulation of neuron projection development; positive regulation of nitric oxide biosynthetic process; positive regulation of nitric-oxide synthase activity; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of protein kinase activity; positive regulation of synaptic transmission, glutamatergic; positive regulation of translation; positive regulation of ubiquitin-dependent protein catabolic process; protein autophosphorylation; protein phosphorylation; protein-containing complex assembly; regulation of actin cytoskeleton reorganization; regulation of calcium-mediated signaling; regulation of cell adhesion; regulation of cell shape; regulation of cGMP-mediated signaling; regulation of establishment of cell polarity; regulation of inositol trisphosphate biosynthetic process; regulation of macrophage chemotaxis; regulation of NMDA receptor activity; regulation of release of sequestered calcium ion into cytosol; regulation of synaptic plasticity; regulation of ubiquitin-dependent protein catabolic process; response to calcium ion; response to cAMP; response to cocaine; response to ethanol; response to glucose; response to hormone; response to hydrogen peroxide; response to hypoxia; response to immobilization stress; response to lithium ion; response to mechanical stimulus; response to osmotic stress; signal complex assembly; signal transduction; sprouting angiogenesis; stress fiber assembly; tumor necrosis factor-mediated signaling pathway; vascular endothelial growth factor receptor signaling pathway
Reference #:  Q14289 (UniProtKB)
Alt. Names/Synonyms: CADTK; CAK beta; CAK-beta; CAKB; Calcium-dependent tyrosine kinase; Cell adhesion kinase beta; FADK 2; FADK2; FAK2; Focal adhesion kinase 2; PKB; Proline-rich tyrosine kinase 2; protein kinase B; protein tyrosine kinase 2 beta; Protein-tyrosine kinase 2-beta; PTK; PTK2B; PTK2B protein tyrosine kinase 2 beta; PYK2; RAFTK; Related adhesion focal tyrosine kinase
Gene Symbols: PTK2B
Molecular weight: 115,875 Da
Basal Isoelectric point: 5.91  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Pyk2

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Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  InnateDB  |  Ensembl Protein