GDI2 Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Belongs to the Rab GDI family. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: G protein regulator, misc.; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 10p15.1
Cellular Component:  azurophil granule lumen; cytoplasm; cytosol; extracellular region; Golgi apparatus; membrane; secretory granule lumen; synapse
Molecular Function:  GTPase activator activity; protein binding; Rab GDP-dissociation inhibitor activity; small GTPase binding
Biological Process:  neutrophil degranulation; positive regulation of GTPase activity; protein transport; regulation of small GTPase mediated signal transduction; signal transduction; small GTPase mediated signal transduction
Reference #:  P50395 (UniProtKB)
Alt. Names/Synonyms: epididymis secretory sperm binding protein Li 46e; FLJ16452; FLJ37352; GDI-2; GDI2; GDIB; GDP dissociation inhibitor 2; Guanosine diphosphate dissociation inhibitor 2; HEL-S-46e; Rab GDI beta; Rab GDP dissociation inhibitor beta; rab GDP-dissociation inhibitor, beta; RABGDIB
Gene Symbols: GDI2
Molecular weight: 50,663 Da
Basal Isoelectric point: 6.11  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein