|
GDI2
Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Belongs to the Rab GDI family. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: G protein regulator, misc.; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 10p15.1 |
|
Cellular Component:
azurophil granule lumen; cytoplasm; cytosol; extracellular region; Golgi apparatus; membrane; secretory granule lumen; synapse
|
|
Molecular Function:
GTPase activator activity; protein binding; Rab GDP-dissociation inhibitor activity; small GTPase binding
|
|
Biological Process:
negative regulation of cilium assembly; negative regulation of protein localization to cilium; protein transport; signal transduction; small GTPase mediated signal transduction; vesicle-mediated transport
|
|
Reference #:
P50395
(UniProtKB)
|
|
Alt. Names/Synonyms: epididymis secretory sperm binding protein Li 46e; FLJ16452; FLJ37352; GDI-2; GDI2; GDIB; GDP dissociation inhibitor 2; Guanosine diphosphate dissociation inhibitor 2; HEL-S-46e; Rab GDI beta; Rab GDP dissociation inhibitor beta; rab GDP-dissociation inhibitor, beta; RABGDIB
|
|
Gene Symbols: GDI2
|
|
Molecular weight:
50,663 Da
|
|
Basal Isoelectric point:
6.11
Predict pI for various phosphorylation states
|
