Cofilin-1 a cytoskeletal protein that controls actin depolymerization. Has a 5-10-fold higher affinity for ATP-actin monomers than cofilin-1. May promote filament assembly rather than disassembly. Two alternatively spliced variants are described. Isoform b is expressed predominantly in skeletal muscle and heart, while isoform a is expressed in various tissues. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis; Nuclear receptor co-regulator
Cellular Component:  actin cytoskeleton; cytoplasm; lamellipodium; lamellipodium membrane; nuclear matrix; ruffle membrane
Molecular Function:  actin filament binding
Biological Process:  actin filament depolymerization; cytoskeleton organization; regulation of cell morphogenesis
Reference #:  P10668 (UniProtKB)
Alt. Names/Synonyms: CFL1; COF1; Cofilin-1
Gene Symbols: COFILIN
Molecular weight: 18,519 Da
Basal Isoelectric point: 8.16  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Microtubule Dynamics  |  TGF-ß Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  NURSA