Cofilin-1 Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Required for neural tube morphogenesis and neural crest cell migration. Belongs to the actin-binding proteins ADF family. Widely distributed in various tissues. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis; Nuclear receptor co-regulator
Cellular Component:  actin cytoskeleton; cytoplasm; lamellipodium; lamellipodium membrane; nuclear matrix; ruffle membrane
Molecular Function:  actin filament binding
Biological Process:  actin filament depolymerization; cytoskeleton organization; regulation of cell morphogenesis
Reference #:  P10668 (UniProtKB)
Alt. Names/Synonyms: CFL1; COF1; Cofilin-1
Gene Symbols: COFILIN
Molecular weight: 18,519 Da
Basal Isoelectric point: 8.16  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Microtubule Dynamics  |  TGF-ß Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  NURSA