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PKN2
PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis. (Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. Ubiquitous. Expressed in numerous tumor cell lines, especially in bladder tumor cells. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: AGC group; EC 2.7.11.13; Kinase, protein; PKN family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of human Ortholog: 1p22.2 |
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Cellular Component:
apical junction complex; centrosome; cleavage furrow; cytoplasm; cytosol; intermediate filament cytoskeleton; lamellipodium; midbody; nuclear body; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; protein-containing complex
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Molecular Function:
ATP binding; calcium-dependent protein kinase C activity; histone deacetylase binding; kinase activity; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; RNA polymerase binding; small GTPase binding
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Biological Process:
apical junction assembly; apoptotic process; cell adhesion; cell cycle; cell division; cell projection organization; epithelial cell migration; intracellular signal transduction; peptidyl-serine phosphorylation; positive regulation of cytokinesis; positive regulation of mitotic cell cycle; positive regulation of viral genome replication; protein phosphorylation; regulation of cell motility; signal transduction
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Reference #:
Q16513
(UniProtKB)
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Alt. Names/Synonyms: cardiolipin-activated protein kinase Pak2; MGC150606; MGC71074; Pak-2; PAK2; PKN gamma; PKN2; PRK2; PRKCL2; PRO2042; Protein kinase C-like 2; protein kinase N2; Protein-kinase C-related kinase 2; Serine/threonine-protein kinase N2; STK7
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Gene Symbols: PKN2
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Molecular weight:
112,035 Da
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Basal Isoelectric point:
5.95
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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