LIG4 Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. Belongs to the ATP-dependent DNA ligase family. Testis, thymus, prostate and heart. Note: This description may include information from UniProtKB.
Protein type: EC; Ligase
Chromosomal Location of Human Ortholog: 13q33.3
Cellular Component:  condensed chromosome; cytoplasmic ribonucleoprotein granule; DNA ligase IV complex; DNA-dependent protein kinase-DNA ligase 4 complex; nonhomologous end joining complex; nuclear chromosome, telomeric region; nucleoplasm; nucleus
Molecular Function:  ATP binding; DNA binding; DNA ligase (ATP) activity; DNA ligase activity; ligase activity; metal ion binding; protein binding; protein C-terminus binding
Biological Process:  cell cycle; cell division; cell proliferation; cellular response to ionizing radiation; cellular response to lithium ion; central nervous system development; chromosome organization; DNA biosynthetic process; DNA ligation; DNA ligation involved in DNA recombination; DNA ligation involved in DNA repair; DNA replication; double-strand break repair; double-strand break repair via classical nonhomologous end joining; double-strand break repair via nonhomologous end joining; establishment of integrated proviral latency; in utero embryonic development; isotype switching; negative regulation of neuron apoptotic process; neuron apoptotic process; nucleotide-excision repair, DNA gap filling; positive regulation of chromosome organization; positive regulation of fibroblast proliferation; positive regulation of neurogenesis; pro-B cell differentiation; response to gamma radiation; response to X-ray; single strand break repair; somatic stem cell population maintenance; T cell differentiation in thymus; T cell receptor V(D)J recombination; V(D)J recombination
Disease: Lig4 Syndrome; Myeloma, Multiple
Reference #:  P49917 (UniProtKB)
Alt. Names/Synonyms: DNA joinase; DNA ligase 4; DNA ligase IV; DNA repair enzyme; DNLI4; LIG4; ligase IV, DNA, ATP-dependent; Polydeoxyribonucleotide synthase [ATP] 4; polynucleotide ligase; sealase
Gene Symbols: LIG4
Molecular weight: 103,971 Da
Basal Isoelectric point: 8.17  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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