LIG4 Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. Belongs to the ATP-dependent DNA ligase family. Testis, thymus, prostate and heart. Note: This description may include information from UniProtKB.
Protein type: EC; Ligase
Chromosomal Location of mouse Ortholog: 8|8 A1.1
Cellular Component:  condensed chromosome; cytoplasmic ribonucleoprotein granule; DNA ligase IV complex; DNA-dependent protein kinase-DNA ligase 4 complex; nonhomologous end joining complex; nucleoplasm; nucleus
Molecular Function:  ATP binding; DNA binding; DNA ligase (ATP) activity; DNA ligase activity; ligase activity; metal ion binding; nucleotide binding; protein binding; protein C-terminus binding
Biological Process:  cell cycle; cell division; cell proliferation; cellular response to DNA damage stimulus; cellular response to ionizing radiation; central nervous system development; chromosome organization; DNA biosynthetic process; DNA ligation; DNA ligation involved in DNA recombination; DNA ligation involved in DNA repair; DNA recombination; DNA repair; DNA replication; double-strand break repair; double-strand break repair via classical nonhomologous end joining; double-strand break repair via nonhomologous end joining; immunoglobulin V(D)J recombination; in utero embryonic development; isotype switching; negative regulation of neuron apoptotic process; neuron apoptotic process; nucleotide-excision repair, DNA gap filling; positive regulation of chromosome organization; positive regulation of fibroblast proliferation; positive regulation of neurogenesis; pro-B cell differentiation; response to gamma radiation; response to ionizing radiation; response to X-ray; single strand break repair; somatic stem cell population maintenance; T cell differentiation in thymus; T cell receptor V(D)J recombination; V(D)J recombination
Reference #:  Q8BTF7 (UniProtKB)
Alt. Names/Synonyms: 5830471N16Rik; DNA ligase 4; DNA ligase IV; DNLI4; Lig4; ligase IV, DNA, ATP-dependent; Polydeoxyribonucleotide synthase [ATP] 4; tiny
Gene Symbols: Lig4
Molecular weight: 104,120 Da
Basal Isoelectric point: 8.4  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene