PKN1 PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. Found ubiquitously. Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas. Expressed in numerous tumor cell lines, especially in breast tumor cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: AGC group; EC; Kinase, protein; PKN family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of human Ortholog: 19p13.12
Cellular Component:  cleavage furrow; cytoplasm; cytosol; endosome; midbody; nucleoplasm; nucleus; protein-containing complex
Molecular Function:  androgen receptor binding; ATP binding; chromatin binding; GTP-Rho binding; histone binding; histone deacetylase binding; histone kinase activity (H3-T11 specific); nuclear receptor transcription coactivator activity; protein binding; protein kinase activity; protein kinase C activity; protein kinase C binding; protein serine/threonine kinase activity; Rac GTPase binding
Biological Process:  activation of JUN kinase activity; B cell apoptotic process; B cell homeostasis; epithelial cell migration; histone H3-T11 phosphorylation; hyperosmotic response; negative regulation of B cell proliferation; negative regulation of protein kinase activity; positive regulation of nucleic acid-templated transcription; protein phosphorylation; regulation of cell motility; regulation of germinal center formation; regulation of immunoglobulin production; regulation of transcription by RNA polymerase II; renal system process; signal transduction; spleen development
Reference #:  Q16512 (UniProtKB)
Alt. Names/Synonyms: DBK; MGC46204; PAK-1; PAK1; PKN; PKN-ALPHA; PKN1; PRK1; PRKCL1; Protease-activated kinase 1; Protein kinase C-like 1; Protein kinase C-like PKN; protein kinase C-related kinase 1; protein kinase N1; Protein kinase PKN-alpha; Protein-kinase C-related kinase 1; serine-threonine kinase N; Serine-threonine protein kinase N; serine/threonine protein kinase N; Serine/threonine-protein kinase N1
Gene Symbols: PKN1
Molecular weight: 103,932 Da
Basal Isoelectric point: 5.99  Predict pI for various phosphorylation states
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