SON RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1. Widely expressed, with the higher expression seen in leukocyte and heart. 10 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; RNA-binding
Chromosomal Location of Human Ortholog: 16 C3.3-C4|16 53.22 cM
Cellular Component:  nuclear speck; nucleus
Molecular Function:  DNA binding; nucleic acid binding; protein binding; RNA binding; RS domain binding
Biological Process:  cell cycle; microtubule cytoskeleton organization; mitotic cytokinesis; mRNA processing; negative regulation of apoptotic process; regulation of cell cycle; regulation of mRNA splicing, via spliceosome; regulation of RNA splicing; RNA splicing
Reference #:  Q9QX47 (UniProtKB)
Alt. Names/Synonyms: 2900011L12Rik; AA409051; AU067731; C81487; mKIAA1019; Negative regulatory element-binding protein; NRE-binding protein; Nrebp; Protein SON; Son; Son cell proliferation protein; Son DNA binding protein
Gene Symbols: Son
Molecular weight: 265,651 Da
Basal Isoelectric point: 5.46  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene