CNOT4 Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins. Involved in activation of the JAK/STAT pathway. Catalyzes ubiquitination of methylated RBM15. 9 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; EC; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 6|6 B1
Cellular Component:  CCR4-NOT complex; cytoplasm; nucleus
Molecular Function:  metal ion binding; nucleic acid binding; RNA binding; transferase activity; ubiquitin-protein transferase activity
Biological Process:  protein autoubiquitination; protein ubiquitination; regulation of megakaryocyte differentiation; ubiquitin-dependent protein catabolic process
Reference #:  Q8BT14 (UniProtKB)
Alt. Names/Synonyms: CCR4-associated factor 4; CCR4-NOT transcription complex subunit 4; CCR4-NOT transcription complex, subunit 4; Cnot4; E3 ubiquitin-protein ligase CNOT4; negative regulator of transcription 4; Not4; Not4h; Not4hp; Potential transcriptional repressor NOT4Hp; transcriptional repressor NOT4Hp
Gene Symbols: Cnot4
Molecular weight: 63,474 Da
Basal Isoelectric point: 6.58  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene