Kaiso Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1. Expressed in vascular endothelium. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: Xq24
Cellular Component:  cytosol; nucleolus; nucleoplasm; nucleus; plasma membrane
Molecular Function:  DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding; methyl-CpG binding; protein binding; sequence-specific DNA binding
Biological Process:  intracellular signal transduction; negative regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; Wnt signaling pathway
Reference #:  Q86T24 (UniProtKB)
Alt. Names/Synonyms: KAISO; kaiso transcription factor; Transcriptional regulator Kaiso; WUGSC:H_DJ525N14.1; ZBTB33; zinc finger and BTB domain containing 33; Zinc finger and BTB domain-containing protein 33; ZNF-kaiso; ZNF348
Gene Symbols: ZBTB33
Molecular weight: 74,484 Da
Basal Isoelectric point: 4.97  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics
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Protein Structure Not Found.

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