FAM120A May participate in mRNA transport in the cytoplasm. Critical component of the oxidative stress-induced survival signaling. Activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. Binds RNA and promotes the secretion of IGF-II. May play a pivotal role in the progression of scirrhous-type gastric cancer by supporting cancer cell survival in environments with various oxidative stresses. Belongs to the constitutive coactivator of PPAR-gamma family. Ubiquitously expressed. Highly expressed in scirrhous-type gastric cancer tissues compared with normal gastric mucosa (at protein level). 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA-binding; Tumor suppressor
Chromosomal Location of human Ortholog: 9q22.31
Cellular Component:  cytosol; nucleus; plasma membrane
Reference #:  Q9NZB2 (UniProtKB)
Alt. Names/Synonyms: C9orf10; Constitutive coactivator of PPAR-gamma-like protein 1; DNA polymerase-transactivated protein 1; DNA polymerase-transactivated protein 5; DNAPTP1; DNAPTP5; F120A; FAM120A; family with sequence similarity 120A; HBVPTPAP; KIAA0183; MGC111527; MGC133257; OSSA; oxidative stess-associated Src activator; Oxidative stress-associated Src activator; Protein FAM120A
Gene Symbols: FAM120A
Molecular weight: 121,888 Da
Basal Isoelectric point: 9.07  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein