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FAM120A
May participate in mRNA transport in the cytoplasm. Critical component of the oxidative stress-induced survival signaling. Activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. Binds RNA and promotes the secretion of IGF-II. May play a pivotal role in the progression of scirrhous-type gastric cancer by supporting cancer cell survival in environments with various oxidative stresses. Belongs to the constitutive coactivator of PPAR-gamma family. Ubiquitously expressed. Highly expressed in scirrhous-type gastric cancer tissues compared with normal gastric mucosa (at protein level). 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: RNA-binding; Tumor suppressor |
| Chromosomal Location of human Ortholog: 9q22.31 |
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Cellular Component:
cytosol; nucleus; plasma membrane
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Reference #:
Q9NZB2
(UniProtKB)
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Alt. Names/Synonyms: C9orf10; Constitutive coactivator of PPAR-gamma-like protein 1; DNA polymerase-transactivated protein 1; DNA polymerase-transactivated protein 5; DNAPTP1; DNAPTP5; F120A; FAM120A; family with sequence similarity 120A; HBVPTPAP; KIAA0183; MGC111527; MGC133257; OSSA; oxidative stess-associated Src activator; Oxidative stress-associated Src activator; Protein FAM120A
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Gene Symbols: FAM120A
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Molecular weight:
121,888 Da
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Basal Isoelectric point:
9.07
Predict pI for various phosphorylation states
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