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MAPKAPK5
Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Expressed ubiquitously. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: CAMK group; EC 2.7.11.1; Kinase, protein; MAPKAPK family; MAPKAPK subfamily; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor |
| Chromosomal Location of human Ortholog: 12q24.12-q24.13 |
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Cellular Component:
cytoplasm; cytosol; nucleoplasm; nucleus; protein-containing complex; septin cytoskeleton
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Molecular Function:
ATP binding; calcium-dependent protein serine/threonine kinase activity; calmodulin binding; calmodulin-dependent protein kinase activity; MAP kinase kinase activity; mitogen-activated protein kinase binding; p53 binding; protein binding; protein serine kinase activity; protein serine/threonine kinase activity
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Biological Process:
cellular senescence; intracellular signal transduction; MAPK cascade; negative regulation of TOR signaling; peptidyl-serine phosphorylation; positive regulation of dendritic spine development; positive regulation of telomerase activity; positive regulation of telomere capping; positive regulation of telomere maintenance via telomerase; protein autophosphorylation; Ras protein signal transduction; regulation of signal transduction by p53 class mediator; regulation of translation; signal transduction; stress-induced premature senescence
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Disease: Neurocardiofaciodigital Syndrome
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Reference #:
Q8IW41
(UniProtKB)
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Alt. Names/Synonyms: MAP kinase-activated protein kinase 5; MAPK activated protein kinase 5; MAPK-activated protein kinase 5; MAPK5; MAPKAP kinase 5; MAPKAP-K5; MAPKAPK-5; MAPKAPK5; mitogen-activated protein kinase-activated protein kinase 5; MK-5; MK5; p38-regulated/activated protein kinase; PRAK
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Gene Symbols: MAPKAPK5
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Molecular weight:
54,220 Da
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Basal Isoelectric point:
7.66
Predict pI for various phosphorylation states
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CST Pathways:
Microtubule Dynamics
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Regulation of P38 MAPKs
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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