EIF3M Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. (Microbial infection) May favor virus entry in case of infection with herpes simplex virus 1 (HSV1) or herpes simplex virus 2 (HSV2). Belongs to the eIF-3 subunit M family. Broadly expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Translation initiation
Chromosomal Location of Human Ortholog: 11p13
Cellular Component:  cytosol; eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; eukaryotic translation initiation factor 3 complex, eIF3m
Molecular Function:  protein binding; translation initiation factor binding
Biological Process:  formation of cytoplasmic translation initiation complex; translational initiation
Reference #:  Q7L2H7 (UniProtKB)
Alt. Names/Synonyms: B5; B5 receptor; dendritic cell protein; EIF3M; Eukaryotic translation initiation factor 3 subunit M; eukaryotic translation initiation factor 3, subunit M; Fetal lung protein B5; FLJ29030; GA17; hFL-B5; HFLB5; PCI domain containing 1 (herpesvirus entry mediator); PCI domain-containing protein 1; PCID1
Gene Symbols: EIF3M
Molecular weight: 42,503 Da
Basal Isoelectric point: 5.41  Predict pI for various phosphorylation states
CST Pathways:  Translational Control
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EIF3M

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene