KPNA2 Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Belongs to the importin alpha family. Expressed ubiquitously. Note: This description may include information from UniProtKB.
Protein type: Karyopherin; Nuclear import; Nucleoporin
Chromosomal Location of Human Ortholog: 17q24.2
Cellular Component:  cytoplasm; cytosol; extrinsic component of postsynaptic specialization membrane; glutamatergic synapse; host cell; nucleoplasm
Molecular Function:  histone deacetylase binding; nuclear import signal receptor activity; nuclear localization sequence binding; protein binding
Biological Process:  DNA metabolic process; entry of viral genome into host nucleus through nuclear pore complex via importin; modulation by virus of host process; NLS-bearing protein import into nucleus; positive regulation of viral life cycle; postsynapse to nucleus signaling pathway; regulation of DNA recombination
Reference #:  P52292 (UniProtKB)
Alt. Names/Synonyms: IMA1; IMA2; importin alpha 1; importin alpha 2; Importin subunit alpha-1; Importin subunit alpha-2; importin-alpha-P1; IPOA1; karyopherin alpha 2; karyopherin alpha 2 (RAG cohort 1, importin alpha 1); karyopherin subunit alpha 2; Karyopherin subunit alpha-2; KPNA2; pendulin; QIP2; RAG cohort 1; RAG cohort protein 1; RCH1; SRP1; SRP1-alpha; SRP1alpha
Gene Symbols: KPNA2
Molecular weight: 57,862 Da
Basal Isoelectric point: 5.25  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene