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SYT2
Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. Plays a role in dendrite formation by melanocytes. Belongs to the synaptotagmin family. Expressed in melanocytes (PubMed:23999003). Note: This description may include information from UniProtKB.
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| Protein type: Calcium-binding; Lipid-binding; Membrane protein, integral; Vesicle |
| Chromosomal Location of mouse Ortholog: 1 E4|1 58.24 cM |
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Cellular Component:
axon; cytoplasm; cytoplasmic vesicle; dense core granule; exocytic vesicle; membrane; neuromuscular junction; plasma membrane; synapse; synaptic vesicle membrane
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Molecular Function:
calcium ion binding; calcium-dependent phospholipid binding; clathrin binding; inositol 1,3,4,5 tetrakisphosphate binding; metal ion binding; phosphatidylserine binding; protein binding; syntaxin binding
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Biological Process:
calcium ion-regulated exocytosis of neurotransmitter; calcium-dependent activation of synaptic vesicle fusion; cell differentiation; cellular response to calcium ion; positive regulation of dendrite extension; regulation of calcium ion-dependent exocytosis; regulation of dopamine secretion; synaptic vesicle endocytosis
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Reference #:
P46097
(UniProtKB)
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Alt. Names/Synonyms: Inositol polyphosphate-binding protein; IP4-binding protein; IP4BP; KIAA4194; mKIAA4194; R74640; synaptotagmin 2; Synaptotagmin II; Synaptotagmin-2; Syt2; SytII
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Gene Symbols: Syt2
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Molecular weight:
47,263 Da
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Basal Isoelectric point:
8.18
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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