SYT2
Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. Plays a role in dendrite formation by melanocytes. Belongs to the synaptotagmin family. Expressed in melanocytes (PubMed:23999003). Note: This description may include information from UniProtKB.
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Protein type: Calcium-binding; Lipid-binding; Membrane protein, integral; Vesicle |
Chromosomal Location of human Ortholog: 1q32.1 |
Cellular Component:
axon; chromaffin granule membrane; clathrin-coated endocytic vesicle membrane; dense core granule; exocytic vesicle; plasma membrane; synaptic vesicle membrane
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Molecular Function:
calcium ion binding; calcium-dependent phospholipid binding; clathrin binding; inositol 1,3,4,5 tetrakisphosphate binding; phosphatidylserine binding; protein binding; syntaxin binding
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Biological Process:
calcium ion-regulated exocytosis of neurotransmitter; cell differentiation; cellular response to calcium ion; positive regulation of dendrite extension; regulation of calcium ion-dependent exocytosis; regulation of dopamine secretion; synaptic vesicle endocytosis
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Disease: Myasthenic Syndrome, Congenital, 7b, Presynaptic, Autosomal Recessive; Myasthenic Syndrome, Presynaptic, Congenital, With Or Without Motor Neuropathy
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Reference #:
Q8N9I0
(UniProtKB)
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Alt. Names/Synonyms: CMS7; FLJ42519; MYSPC; synaptotagmin 2; Synaptotagmin II; Synaptotagmin-2; SYT2; SytII
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Gene Symbols: SYT2
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Molecular weight:
46,872 Da
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Basal Isoelectric point:
8.18
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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