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UBXN1
Ubiquitin-binding protein that plays a role in the modulation of innate immune response. Blocks both the RIG-I-like receptors (RLR) and NF-kappa-B pathways. Following viral infection, UBXN1 is induced and recruited to the RLR component MAVS. In turn, interferes with MAVS oligomerization, and disrupts the MAVS/TRAF3/TRAF6 signalosome. This function probably serves as a brake to prevent excessive RLR signaling. Interferes with the TNFalpha-triggered NF-kappa-B pathway by interacting with cellular inhibitors of apoptosis proteins (cIAPs) and thereby inhibiting their recruitment to TNFR1. Prevents also the activation of NF-kappa-B by associating with CUL1 and thus inhibiting NF-kappa-B inhibitor alpha/NFKBIA degradation that remains bound to NF-kappa-B. Interacts with the BRCA1-BARD1 heterodimer and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1 leads to the inhibition of the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Proteasome complex; Ubiquitin conjugating system |
| Chromosomal Location of human Ortholog: 11q12.3 |
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Cellular Component:
cytoplasm; cytosol; endoplasmic reticulum; nucleoplasm; nucleus; VCP-NPL4-UFD1 AAA ATPase complex
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Molecular Function:
ATPase binding; K48-linked polyubiquitin modification-dependent protein binding; K6-linked polyubiquitin modification-dependent protein binding; polyubiquitin modification-dependent protein binding; proteasome regulatory particle binding; protein binding; ubiquitin binding; ubiquitin protein ligase binding
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Biological Process:
negative regulation of ERAD pathway; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of protein K48-linked deubiquitination; negative regulation of protein ubiquitination; negative regulation of ubiquitin-specific protease activity; proteasome-mediated ubiquitin-dependent protein catabolic process
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Reference #:
Q04323
(UniProtKB)
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Alt. Names/Synonyms: 2B28; LOC51035; SAKS1; SAPK substrate protein 1; UBA/UBX 33.3 kDa protein; UBX domain protein 1; UBX domain-containing protein 1; UBXD10; UBXN1
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Gene Symbols: UBXN1
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Molecular weight:
33,325 Da
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Basal Isoelectric point:
5.23
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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