ENaC-alpha Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1A subfamily. Expressed in the female reproductive tract, from the fimbrial end of the fallopian tube to the endometrium (at protein level) (PubMed:22207244). Expressed in kidney (at protein level). In the respiratory tract, expressed in the bronchial epithelium (at protein level). Highly expressed in lung. Detected at intermediate levels in pancreas and liver, and at low levels in heart and placenta (PubMed:22207244). in skin, expressed in keratinocytes, melanocytes and Merkel cells of the epidermal sub-layers, stratum basale, stratum spinosum and stratum granulosum (at protein level) (PubMed:28130590). Expressed in the outer root sheath of the hair follicles (at protein level) (PubMed:28130590). Detected in both peripheral and central cells of the sebaceous gland (at protein level) (PubMed:28130590). Expressed by eccrine sweat glands (at protein level) (PubMed:28130590). In skin, also expressed by arrector pili muscle cells and intradermal adipocytes (PubMed:28130590). Isoform 1 and isoform 2 predominate in all tissues. Expression of isoform 3, isoform 4 and isoform 5 is very low or not detectable, except in lung and heart (PubMed:9575806). 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel
Chromosomal Location of Human Ortholog: 4q42
Cellular Component:  acrosomal vesicle; apical plasma membrane; ciliary membrane; cortical actin cytoskeleton; cytoplasm; cytosol; external side of plasma membrane; extracellular exosome; integral component of membrane; integral component of plasma membrane; membrane; motile cilium; sodium channel complex; sperm principal piece
Molecular Function:  actin binding; ligand-gated sodium channel activity; WW domain binding
Biological Process:  multicellular organismal water homeostasis; regulation of blood pressure; regulation of body fluid levels; sensory perception of taste; sodium ion homeostasis; sodium ion transmembrane transport; sodium ion transport
Reference #:  P37089 (UniProtKB)
Alt. Names/Synonyms: Alpha-ENaC; Alpha-NaCH; Amiloride-sensitive sodium channel subunit alpha; ENaC-alpha; ENACA; Epithelial Na(+) channel subunit alpha; epithelial sodium channel alpha subunit; Nonvoltage-gated sodium channel 1 subunit alpha; Renac; SCNEA; Scnn1a; SCNNA; sodium channel, nonvoltage-gated 1 alpha; sodium channel, nonvoltage-gated, type I, alpha
Gene Symbols: Scnn1a
Molecular weight: 78,888 Da
Basal Isoelectric point: 8.39  Predict pI for various phosphorylation states
CST Pathways:  Insulin Receptor Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene