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HIP14
Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes. Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA. Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT. Also palmitoylates neuronal protein GPM6A as well as SPRED1 and SPRED3. Could also play a role in axonogenesis through the regulation of NTRK1 and the downstream ERK1/ERK2 signaling cascade. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. May play a role in Mg2+ transport. Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane. Palmitoylates CASP6, thereby preventing its dimerization and subsequent activation. Interacts (via ANK repeats) with numerous proteins (via the consensus sequence motif [VIAP]-[VIT]-x-x-Q-P). Interacts (via ANK repeats) with CLIP3, DNAJC5 (via C-terminus), MAP6, SNAP23, SNAP25, EVL. Interacts (via ANK repeats) with HTT; this interaction is inversely correlated to the length of the polyglutamine tract added to the huntingtin protein in Huntington disease. Interacts with SPRED1 and SPRED3. Interacts with GPM6A and OPTN. May interact (via ANK repeats) with SPRED2. May interact with NTRK1; may regulate its localization and function. Expressed in all brain regions. Expression is highest in the cortex, cerebellum, occipital lobe and caudate and lowest in the spinal cord. Expression is also seen in testis, pancreas, heart and kidney. The DHHC domain is required for palmitoyltransferase activity. Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.3.1.225; Membrane protein, integral; Membrane protein, multi-pass; Palmitoyltransferase; Transferase; Tumor suppressor |
| Chromosomal Location of mouse Ortholog: 10|10 D1 |
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Cellular Component:
cell projection; cytoplasmic vesicle; Golgi apparatus; Golgi membrane; Golgi-associated vesicle membrane; intracellular membrane-bounded organelle; membrane; plasma membrane; synapse
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Molecular Function:
acyltransferase activity; identical protein binding; palmitoyltransferase activity; protein binding; protein-cysteine S-myristoyltransferase activity; protein-cysteine S-palmitoyltransferase activity; protein-cysteine S-stearoyltransferase activity; signaling receptor binding; transferase activity
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Biological Process:
axonogenesis; lipoprotein transport; peptidyl-L-cysteine S-palmitoylation; protein palmitoylation; regulation of ERK1 and ERK2 cascade; regulation of neurotrophin TRK receptor signaling pathway; regulation of programmed cell death
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Reference #:
Q80TN5
(UniProtKB)
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Alt. Names/Synonyms: A230053P19Rik; Acyltransferase ZDHHC7; BB187739; D130071N24Rik; DHHC-17; Hip; Hip14; huntingtin interacting protein 14; Huntingtin-interacting protein 14; Kiaa0946; Palmitoyltransferase ZDHHC17; ZDH17; Zdhhc17; Zinc finger DHHC domain-containing protein 17; zinc finger, DHHC domain containing 17
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Gene Symbols: Zdhhc17
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Molecular weight:
72,621 Da
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Basal Isoelectric point:
7.08
Predict pI for various phosphorylation states
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