CTDP1 Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation. Ubiquitously expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Motility/polarity/chemotaxis; Protein phosphatase, Ser/Thr (non-receptor); Transcription initiation complex
Chromosomal Location of Human Ortholog: 18 E3|18 53.48 cM
Cellular Component:  centrosome; cytoplasm; cytoskeleton; intracellular membrane-bounded organelle; midbody; nucleoplasm; nucleus; protein-containing complex; spindle; spindle midzone; spindle pole
Molecular Function:  hydrolase activity; phosphoprotein phosphatase activity; protein binding; RNA polymerase II CTD heptapeptide repeat phosphatase activity; Tat protein binding; TFIIF-class transcription factor complex binding
Biological Process:  cell cycle; cell division; dephosphorylation of RNA polymerase II C-terminal domain; exit from mitosis; negative regulation of cell growth involved in cardiac muscle cell development; positive regulation by host of viral transcription; protein dephosphorylation
Reference #:  Q7TSG2 (UniProtKB)
Alt. Names/Synonyms: 4930563P03Rik; AW553592; CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1; CTD (carboxy-terminal domina, RNA polymerase II, polypeptide A) phosphatase, subunit 1; Ctdp1; Fcp1; RNA polymerase II subunit A C-terminal domain phosphatase; TFIIF-associating CTD phosphatase
Gene Symbols: Ctdp1
Molecular weight: 104,554 Da
Basal Isoelectric point: 5.23  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene