PKR a protein kinase of the PEK family. Upon binding double-stranded RNA, it becomes autophosphorylated and activated. Phosphorylates and inhibits the alpha subunit of eIF2 alpha, which leads to an inhibition of the initiation of protein synthesis. Controls the activation of several transcription factors such as NF-kappaB, p53 and Stats. Mediates apoptosis induced by many different stimuli, such as LPS, TNF-alpha, viral infection and serum starvation. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.2; EC 2.7.11.1; Kinase, protein; Other group; PEK family; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation
Chromosomal Location of Human Ortholog: 2p22.2
Cellular Component:  cytoplasm; cytosol; nucleus; perinuclear region of cytoplasm; ribosome
Molecular Function:  ATP binding; double-stranded RNA binding; eukaryotic translation initiation factor 2alpha kinase activity; identical protein binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein kinase activity; protein phosphatase regulator activity; protein serine/threonine kinase activity
Biological Process:  activation of MAPKK activity; cellular response to amino acid starvation; defense response to virus; endoplasmic reticulum unfolded protein response; evasion or tolerance by virus of host immune response; innate immune response; negative regulation of apoptotic process; negative regulation of cell proliferation; negative regulation of osteoblast proliferation; negative regulation of translation; negative regulation of viral genome replication; peptidyl-tyrosine phosphorylation; positive regulation of chemokine production; positive regulation of cytokine production; positive regulation of NF-kappaB transcription factor activity; positive regulation of NIK/NF-kappaB signaling; positive regulation of stress-activated MAPK cascade; protein autophosphorylation; protein phosphorylation; regulation of hematopoietic progenitor cell differentiation; regulation of hematopoietic stem cell differentiation; regulation of hematopoietic stem cell proliferation; regulation of NLRP3 inflammasome complex assembly; regulation of phosphoprotein phosphatase activity; regulation of translational initiation by eIF2 alpha phosphorylation; response to interferon-alpha; response to toxic substance; response to virus; translation
Reference #:  P19525 (UniProtKB)
Alt. Names/Synonyms: double stranded RNA activated protein kinase; E2AK2; eIF-2A protein kinase 2; EIF2AK1; EIF2AK2; Eukaryotic translation initiation factor 2-alpha kinase 2; Interferon-induced, double-stranded RNA-activated protein kinase; interferon-inducible elF2alpha kinase; Interferon-inducible RNA-dependent protein kinase; MGC126524; P1/eIF-2A protein kinase; p68 kinase; PKR; PRKR; Protein kinase RNA-activated; protein kinase, interferon-inducible double stranded RNA dependent
Gene Symbols: EIF2AK2
Molecular weight: 62,094 Da
Basal Isoelectric point: 8.58  Predict pI for various phosphorylation states
CST Pathways:  Translation: eIF2
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PKR

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