AIP May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting. Cellular negative regulator of the hepatitis B virus (HBV) X protein. Widely expressed. Higher levels seen in the heart, placenta and skeletal muscle. Not expressed in the liver. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 19 A|19 3.82 cM
Cellular Component:  aryl hydrocarbon receptor complex; cytoplasm; cytosol; membrane
Molecular Function:  aryl hydrocarbon receptor binding; GAF domain binding; protein binding; transcription coregulator activity; unfolded protein binding
Biological Process:  negative regulation of cyclic-nucleotide phosphodiesterase activity; protein maturation by protein folding; protein targeting to mitochondrion; regulation of protein kinase A signaling; xenobiotic metabolic process
Reference #:  O08915 (UniProtKB)
Alt. Names/Synonyms: AA408703; AH receptor-interacting protein; AIP; Ara9; Aryl-hydrocarbon receptor-interacting protein; AW476050; D19Bwg1412e; Fkbp1; Fkbp16; Xap2
Gene Symbols: Aip
Molecular weight: 37,605 Da
Basal Isoelectric point: 5.97  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene