AIP May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting. Defects in AIP are a cause of growth hormone-secreting pituitary adenoma (GHSPA); also known as familial isolated somatotropinomas (FIS) or isolated familial somatotropinoma (IFS) or familial somatotrophinoma or acromegaly due to pituitary adenoma. Defects in AIP are a cause of ACTH-secreting pituitary adenoma (ASPA); also known as pituitary Cushing disease. A pituary adenoma resulting in excessive production of adrenocorticotropic hormone. This leads to hypersecretion of cortisol by the adrenal glands and ACTH-dependent Cushing syndrome. Clinical manifestations of Cushing syndrome include facial and trunkal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes. Defects in AIP are a cause of prolactin-secreting pituitary adenoma (PSPA); also known as prolactinoma. Prolactin-secreting pituitary adenoma is the most common type of hormonally active pituitary adenoma. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 11q13.2
Cellular Component:  aryl hydrocarbon receptor complex; cytoplasm; cytosol; nucleoplasm
Molecular Function:  aryl hydrocarbon receptor binding; GAF domain binding; protein binding; transcription coactivator activity; transcription factor binding; unfolded protein binding
Biological Process:  interleukin-12-mediated signaling pathway; negative regulation of cyclic-nucleotide phosphodiesterase activity; positive regulation of nucleic acid-templated transcription; protein maturation by protein folding; protein targeting to mitochondrion; regulation of protein kinase A signaling; xenobiotic metabolic process
Disease: Pituitary Adenoma, Acth-secreting; Pituitary Adenoma, Growth Hormone-secreting
Reference #:  O00170 (UniProtKB)
Alt. Names/Synonyms: AH receptor-interacting protein; AIP; ARA9; aryl hydrocarbon receptor interacting protein; aryl hydrocarbon receptor-interacting protein; aryl-hydrocarbon receptor interacting protein; Aryl-hydrocarbon receptor-interacting protein; FKBP16; FKBP37; HBV X-associated protein 2; HBV-X associated protein; Immunophilin homolog ARA9; SMTPHN; XAP-2; XAP2
Gene Symbols: AIP
Molecular weight: 37,636 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene