FKBP8 Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. Widely expressed. Highest levels seen in the brain. Highly abundant in the retina. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Chaperone; EC 5.2.1.8; Isomerase; Membrane protein, integral; Mitochondrial
Chromosomal Location of Human Ortholog: 8|8 B3.3
Cellular Component:  cytosol; endoplasmic reticulum; integral component of endoplasmic reticulum membrane; integral component of membrane; membrane; mitochondrial envelope; mitochondrion; protein-containing complex
Molecular Function:  disordered domain specific binding; identical protein binding; isomerase activity; peptidyl-prolyl cis-trans isomerase activity
Biological Process:  apoptotic process; camera-type eye development; cell fate specification; dorsal/ventral neural tube patterning; dorsal/ventral pattern formation; multicellular organism growth; negative regulation of apoptotic process; negative regulation of protein phosphorylation; neural tube development; positive regulation of BMP signaling pathway; regulation of BMP signaling pathway; regulation of gene expression; smoothened signaling pathway
Reference #:  O35465 (UniProtKB)
Alt. Names/Synonyms: 38 kDa FK506-binding protein; 38 kDa FKBP; 38kDa; FK506 binding protein 8; FK506-binding protein 38; FK506-binding protein 8; FKBP-38; FKBP-8; Fkbp38; Fkbp8; FKBPR38; mFKBP38; Peptidyl-prolyl cis-trans isomerase FKBP8; PPIase FKBP8; Sam11
Gene Symbols: Fkbp8
Molecular weight: 43,529 Da
Basal Isoelectric point: 5.08  Predict pI for various phosphorylation states
Select Structure to View Below

FKBP8

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene