RPA40
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft. Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase |
Chromosomal Location of human Ortholog: 6p21.1 |
Cellular Component:
cytosol; fibrillar center; nucleoplasm; RNA polymerase I complex; RNA polymerase III complex
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Molecular Function:
DNA binding; DNA-directed 5'-3' RNA polymerase activity; protein binding; protein dimerization activity; RNA polymerase I activity; RNA polymerase III activity
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Biological Process:
transcription by RNA polymerase I; transcription by RNA polymerase III
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Disease: Leukodystrophy, Hypomyelinating, 11; Treacher Collins Syndrome 3
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Reference #:
O15160
(UniProtKB)
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Alt. Names/Synonyms: AC40; DNA-directed RNA polymerase I subunit C; DNA-directed RNA polymerases I and III 40 kDa polypeptide; DNA-directed RNA polymerases I and III subunit RPAC1; HLD11; POLR1C; POLR1E; polymerase (RNA) I polypeptide C, 30kDa; polymerase (RNA) I subunit C; RNA polymerase I and III subunit C; RNA polymerase I subunit; RNA polymerase I subunit C; RNA polymerases I and III subunit AC1; RPA39; RPA40; RPA5; RPAC1; RPC40; TCS3
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Gene Symbols: POLR1C
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Molecular weight:
39,250 Da
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Basal Isoelectric point:
5.31
Predict pI for various phosphorylation states
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