RPA40 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft. Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase
Chromosomal Location of Human Ortholog: 6p21.1
Cellular Component:  cytosol; nucleoplasm; nucleus; RNA polymerase III complex
Molecular Function:  DNA binding; DNA-directed 5'-3' RNA polymerase activity; protein binding; protein dimerization activity
Biological Process:  positive regulation of gene expression, epigenetic; positive regulation of type I interferon production; termination of RNA polymerase I transcription; transcription by RNA polymerase I; transcription by RNA polymerase III; transcription elongation from RNA polymerase I promoter; transcription initiation from RNA polymerase I promoter
Disease: Leukodystrophy, Hypomyelinating, 11; Treacher Collins Syndrome 3
Reference #:  O15160 (UniProtKB)
Alt. Names/Synonyms: AC40; DNA-directed RNA polymerase I subunit C; DNA-directed RNA polymerases I and III 40 kDa polypeptide; DNA-directed RNA polymerases I and III subunit RPAC1; POLR1C; POLR1E; polymerase (RNA) I polypeptide C, 30kDa; RNA polymerase I subunit; RNA polymerases I and III subunit AC1; RPA39; RPA40; RPA5; RPAC1; RPC40
Gene Symbols: POLR1C
Molecular weight: 39,250 Da
Basal Isoelectric point: 5.31  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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