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snRNP C
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. Belongs to the U1 small nuclear ribonucleoprotein C family. Note: This description may include information from UniProtKB.
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| Protein type: RNA splicing; RNA-binding; Spliceosome |
| Chromosomal Location of human Ortholog: 6p21.31 |
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Cellular Component:
Cajal body; commitment complex; nucleoplasm; U1 snRNP; U2-type prespliceosome
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Molecular Function:
mRNA binding; protein binding; protein homodimerization activity; single-stranded RNA binding; U1 snRNP binding; zinc ion binding
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Biological Process:
mRNA splicing, via spliceosome; spliceosomal snRNP assembly
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Reference #:
P09234
(UniProtKB)
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Alt. Names/Synonyms: FLJ20302; RU1C; small nuclear ribonucleoprotein polypeptide C; snRNP C; SNRPC; U1 small nuclear ribonucleoprotein C; U1 small nuclear RNP specific C; U1 snRNP C; U1 snRNP protein C; U1-C; U1C; Yhc1
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Gene Symbols: SNRPC
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Molecular weight:
17,394 Da
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Basal Isoelectric point:
9.72
Predict pI for various phosphorylation states
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