snRNP C Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. Belongs to the U1 small nuclear ribonucleoprotein C family. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 6p21.31
Cellular Component:  Cajal body; commitment complex; nucleoplasm; U1 snRNP; U2-type prespliceosome
Molecular Function:  mRNA binding; protein binding; protein homodimerization activity; single-stranded RNA binding; U1 snRNP binding; zinc ion binding
Biological Process:  mRNA splicing, via spliceosome; spliceosomal snRNP assembly
Reference #:  P09234 (UniProtKB)
Alt. Names/Synonyms: FLJ20302; RU1C; small nuclear ribonucleoprotein polypeptide C; snRNP C; SNRPC; U1 small nuclear ribonucleoprotein C; U1 small nuclear RNP specific C; U1 snRNP C; U1 snRNP protein C; U1-C; U1C; Yhc1
Gene Symbols: SNRPC
Molecular weight: 17,394 Da
Basal Isoelectric point: 9.72  Predict pI for various phosphorylation states
Select Structure to View Below

snRNP C

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene