UNK Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes. Belongs to the unkempt family. Note: This description may include information from UniProtKB.
Protein type: RNA-binding; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 17q25.1
Cellular Component:  cytoplasm; polysome
Molecular Function:  metal ion binding; mRNA CDS binding; polysome binding
Biological Process:  cell morphogenesis involved in neuron differentiation; negative regulation of cytoplasmic translation; neuron migration
Reference #:  Q9C0B0 (UniProtKB)
Alt. Names/Synonyms: KIAA1753; RING finger protein unkempt homolog; UNK; unkempt homolog (Drosophila); ZC3H5; ZC3HDC5; Zinc finger CCCH domain-containing protein 5; zinc finger CCCH type domain containing 5; zinc finger CCCH-type containing 5; zinc finger CCCH-type domain containing 5
Gene Symbols: UNK
Molecular weight: 88,084 Da
Basal Isoelectric point: 6.4  Predict pI for various phosphorylation states
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UNK

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene