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YEATS2
Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. Note: This description may include information from UniProtKB.
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| Protein type: Unknown function |
| Chromosomal Location of human Ortholog: 3q27.1 |
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Cellular Component:
ATAC complex; mitotic spindle; NuA4 histone acetyltransferase complex; nucleus
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Molecular Function:
histone binding; modification-dependent protein binding; protein binding; TBP-class protein binding
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Biological Process:
chromatin remodeling; histone acetylation; histone H3 acetylation; histone H3-K14 acetylation; negative regulation of DNA-templated transcription; negative regulation of transcription by RNA polymerase II; regulation of cell cycle; regulation of cell division; regulation of DNA-templated transcription; regulation of embryonic development; regulation of histone deacetylation; regulation of transcription by RNA polymerase II; regulation of tubulin deacetylation
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Disease: Epilepsy, Familial Adult Myoclonic, 4
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Reference #:
Q9ULM3
(UniProtKB)
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Alt. Names/Synonyms: FAME4; FLJ10201; FLJ12841; FLJ13308; FLJ33401; FLJ34335; KIAA1197; YEATS domain containing 2; YEATS domain-containing protein 2; YEATS2; YETS2
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Gene Symbols: YEATS2
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Molecular weight:
150,782 Da
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Basal Isoelectric point:
9.1
Predict pI for various phosphorylation states
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