UBN1 Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly. Belongs to the ubinuclein family. Ubiquitous. Also expressed in numerous tumors and cancer cell lines. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component:  bicellular tight junction; nuclear body; nucleoplasm; nucleus; PML body
Molecular Function:  DNA binding; DNA-binding transcription factor activity; protein binding
Biological Process:  DNA replication-independent nucleosome assembly; regulation of transcription by RNA polymerase II; viral process
Reference #:  Q9NPG3 (UniProtKB)
Alt. Names/Synonyms: HIRA-binding protein; Protein VT4; ubinuclein 1; Ubinuclein-1; Ubiquitously expressed nuclear protein; UBN1; VT; VT4
Gene Symbols: UBN1
Molecular weight: 121,520 Da
Basal Isoelectric point: 9.37  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB