TIMELESS Required for normal progression of S-phase. Involved in the circadian rhythm autoregulatory loop. Negatively regulates CLOCK-NPAS2/BMAL1-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Promotes TIPIN nuclear localiZation. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules. Belongs to the timeless family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 12q13.3
Cellular Component:  nuclear chromatin; nucleoplasm; nucleus; site of double-strand break
Molecular Function:  protein binding; protein heterodimerization activity; protein homodimerization activity
Biological Process:  branching morphogenesis of an epithelial tube; cell cycle phase transition; cell division; cellular response to bleomycin; cellular response to cisplatin; cellular response to DNA damage stimulus; cellular response to hydroxyurea; circadian rhythm; detection of abiotic stimulus; DNA replication; lung development; morphogenesis of an epithelium; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; positive regulation of double-strand break repair; positive regulation of double-strand break repair via homologous recombination; regulation of circadian rhythm
Reference #:  Q9UNS1 (UniProtKB)
Alt. Names/Synonyms: FLJ12640; FLJ20714; hTIM; Protein timeless homolog; TIM; TIM1; TIMELESS; timeless homolog (Drosophila); TIMELESS1
Gene Symbols: TIMELESS
Molecular weight: 138,658 Da
Basal Isoelectric point: 5.28  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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