SAP30L Isoform 1: Functions as transcription repressor, probably via its interaction with histone deacetylase complexes. Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus. Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA. Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import. Isoform 2: Functions as transcription repressor; isoform 2 has lower transcription repressor activity than isoform 1 and isoform 3. Isoform 3: Functions as transcription repressor; its activity is marginally lower than that of isoform 1. Belongs to the SAP30 family. Detected in brain and ovary, and at lower levels in heart, small intestine, lung, kidney, skeletal muscle, stomach and spleen (at protein level) (PubMed:18070604). Ubiquitous; expressed in all tissues tested with highest levels in testis (PubMed:14680513). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nucleolus
Chromosomal Location of Human Ortholog: 5q33.2
Cellular Component:  nucleolus; nucleoplasm; nucleus
Molecular Function:  DNA binding; histone binding; non-sequence-specific DNA binding, bending; nucleosome binding; phosphatidylinositol-5-phosphate binding; protein binding; zinc ion binding
Biological Process:  histone deacetylation
Reference #:  Q9HAJ7 (UniProtKB)
Alt. Names/Synonyms: DKFZp667L2214; FLJ11526; FLJ23595; FLJ36497; HCV non-structural protein 4A-transactivated protein 2; Histone deacetylase complex subunit SAP30L; NS4ATP2; SAP30 like; SAP30-like; SAP30L; Sin3 corepressor complex subunit SAP30L; Sin3-associated protein p30-like; Sin3A associated protein p30-like; SP30L
Gene Symbols: SAP30L
Molecular weight: 20,877 Da
Basal Isoelectric point: 9.43  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein