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SAP30L
Isoform 1: Functions as transcription repressor, probably via its interaction with histone deacetylase complexes. Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus. Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA. Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import. Isoform 2: Functions as transcription repressor; isoform 2 has lower transcription repressor activity than isoform 1 and isoform 3. Isoform 3: Functions as transcription repressor; its activity is marginally lower than that of isoform 1. Belongs to the SAP30 family. Detected in brain and ovary, and at lower levels in heart, small intestine, lung, kidney, skeletal muscle, stomach and spleen (at protein level) (PubMed:18070604). Ubiquitous; expressed in all tissues tested with highest levels in testis (PubMed:14680513). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Nucleolus |
| Chromosomal Location of human Ortholog: 5q33.2 |
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Cellular Component:
fibrillar center; histone deacetylase complex; nucleolus; nucleoplasm; nucleus; Sin3 complex
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Molecular Function:
DNA binding; histone binding; non-sequence-specific DNA binding, bending; nucleosome binding; phosphatidylinositol-5-phosphate binding; protein binding; transcription coregulator activity; zinc ion binding
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Biological Process:
DNA-templated transcription; negative regulation of cell migration; negative regulation of stem cell population maintenance; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of stem cell population maintenance; regulation of DNA-templated transcription
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Reference #:
Q9HAJ7
(UniProtKB)
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Alt. Names/Synonyms: DKFZp667L2214; FLJ11526; FLJ23595; FLJ36497; HCV non-structural protein 4A-transactivated protein 2; Histone deacetylase complex subunit SAP30L; NS4ATP2; SAP30 like; SAP30-like; SAP30L; Sin3 corepressor complex subunit SAP30L; Sin3-associated protein p30-like; Sin3A associated protein p30-like; SP30L
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Gene Symbols: SAP30L
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Molecular weight:
20,877 Da
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Basal Isoelectric point:
9.43
Predict pI for various phosphorylation states
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