RIF1 Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs. In response to DNA damage, interacts with ATM-phosphorylated TP53BP1. Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs. Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs. In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase. Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs. Promotes NHEJ of dysfunctional telomeres. Belongs to the RIF1 family. Highly expressed in testis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage
Chromosomal Location of Human Ortholog: 2q23.3
Cellular Component:  chromosome, telomeric region; condensed chromosome; cytoplasm; female pronucleus; male pronucleus; nuclear body; nuclear chromatin; nuclear membrane; nucleoplasm; nucleus; plasma membrane; site of double-strand break; spindle midzone
Molecular Function:  protein binding
Biological Process:  cell cycle; cellular response to DNA damage stimulus; cellular response to leukemia inhibitory factor; chromatin silencing at telomere; double-strand break repair via nonhomologous end joining; negative regulation of double-strand break repair via homologous recombination; negative regulation of transcription by RNA polymerase II; positive regulation of double-strand break repair via nonhomologous end joining; positive regulation of histone H3-K9 methylation; positive regulation of isotype switching; stem cell population maintenance; telomere maintenance; telomere maintenance in response to DNA damage
Reference #:  Q5UIP0 (UniProtKB)
Alt. Names/Synonyms: DKFZp434D1026; DKFZp781N1478; FLJ12870; RAP1 interacting factor homolog (yeast); Rap1-interacting factor 1 homolog; RIF1; Telomere-associated protein RIF1
Gene Symbols: RIF1
Molecular weight: 274,466 Da
Basal Isoelectric point: 5.39  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein