RERE Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. Widely expressed. Expressed in tumor cell lines. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Transcription factor
Chromosomal Location of Human Ortholog: 1p36.23
Cellular Component:  histone deacetylase complex; nucleus
Molecular Function:  chromatin binding; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; sequence-specific DNA binding; transcription coactivator activity; zinc ion binding
Biological Process:  branching morphogenesis of a nerve; cerebellar granule cell precursor proliferation; cerebellar Purkinje cell layer maturation; chromatin remodeling; dendrite morphogenesis; negative regulation of nucleic acid-templated transcription; positive regulation of nucleic acid-templated transcription; radial glia guided migration of Purkinje cell; regulation of transcription by RNA polymerase II
Disease: Neurodevelopmental Disorder With Or Without Anomalies Of The Brain, Eye, Or Heart
Reference #:  Q9P2R6 (UniProtKB)
Alt. Names/Synonyms: ARG; arginine-glutamic acid dipeptide (RE) repeats; arginine-glutamic acid dipeptide repeats; Arginine-glutamic acid dipeptide repeats protein; ARP; ATN1L; atrophin 2; atrophin-1 like protein; atrophin-1 related protein; Atrophin-1-like protein; Atrophin-1-related protein; DNB1; FLJ38775; KIAA0458; NEDBEH; RERE
Gene Symbols: RERE
Molecular weight: 172,424 Da
Basal Isoelectric point: 7.44  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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