AHRR
Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site. Highly expressed in testis, lung, ovary, spleen and pancreas. Highly expressed in mononuclear cells (MNCs) from umbilical cord blood. Isoform 3 is highly expressed in lung, kidney, spleen and thymus. Down-regulated malignant tissue from different anatomical origins, including colon, breast, lung, stomach, cervix, and ovary. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Transcription factor |
Chromosomal Location of human Ortholog: 5p15.33 |
Cellular Component:
aryl hydrocarbon receptor complex; chromatin; cytosol; nucleoplasm; nucleus
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Molecular Function:
DNA-binding transcription factor activity, RNA polymerase II-specific; nuclear receptor activity; protein binding; protein dimerization activity; transcription cis-regulatory region binding
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Biological Process:
intracellular receptor signaling pathway; regulation of transcription by RNA polymerase II
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Reference #:
A9YTQ3
(UniProtKB)
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Alt. Names/Synonyms: AHH; AHHR; AhR repressor; AHRR; aryl hydrocarbon hydroxylase regulator; aryl hydrocarbon receptor regulator; Aryl hydrocarbon receptor repressor; aryl-hydrocarbon receptor repressor; arylhydrocarbon receptor repressor; BHLHE77; Class E basic helix-loop-helix protein 77; dioxin receptor repressor; KIAA1234; MGC167813; MGC176630
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Gene Symbols: AHRR
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Molecular weight:
76,265 Da
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Basal Isoelectric point:
9.14
Predict pI for various phosphorylation states
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