AHRR Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site. Highly expressed in testis, lung, ovary, spleen and pancreas. Highly expressed in mononuclear cells (MNCs) from umbilical cord blood. Isoform 3 is highly expressed in lung, kidney, spleen and thymus. Down-regulated malignant tissue from different anatomical origins, including colon, breast, lung, stomach, cervix, and ovary. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Chromosomal Location of human Ortholog: 5p15.33
Cellular Component:  cytosol; nucleoplasm
Molecular Function:  DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; protein dimerization activity
Biological Process:  xenobiotic metabolic process
Reference #:  A9YTQ3 (UniProtKB)
Alt. Names/Synonyms: AHH; AHHR; AhR repressor; AHRR; aryl hydrocarbon hydroxylase regulator; aryl hydrocarbon receptor regulator; Aryl hydrocarbon receptor repressor; aryl-hydrocarbon receptor repressor; arylhydrocarbon receptor repressor; BHLHE77; Class E basic helix-loop-helix protein 77; dioxin receptor repressor; KIAA1234; MGC167813; MGC176630
Gene Symbols: AHRR
Molecular weight: 76,265 Da
Basal Isoelectric point: 9.14  Predict pI for various phosphorylation states
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AHRR

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein