PRDX6 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis. Belongs to the peroxiredoxin family. Prx6 subfamily. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - phenylalanine; EC; EC; Energy Metabolism - methane; Oxidoreductase; Phospholipase
Chromosomal Location of rat Ortholog: 13q22
Cellular Component:  cytoplasm; cytosol; lysosome; mitochondrion; nucleus; perinuclear region of cytoplasm
Molecular Function:  1-acylglycerophosphocholine O-acyltransferase activity; calcium-independent phospholipase A2 activity; glutathione peroxidase activity; identical protein binding; peroxidase activity; peroxiredoxin activity; phospholipase A2 activity; protein binding; ubiquitin protein ligase binding
Biological Process:  bleb assembly; cell redox homeostasis; cellular oxidant detoxification; glycerophospholipid catabolic process; hydrogen peroxide catabolic process; positive regulation of mRNA splicing, via spliceosome; response to oxidative stress; response to reactive oxygen species
Reference #:  O35244 (UniProtKB)
Alt. Names/Synonyms: 1-Cys peroxiredoxin; 1-Cys PRX; Acidic calcium-independent phospholipase A2; Aipla2; Antioxidant protein 2; Aop2; Non-selenium glutathione peroxidase; NSGPx; peroxiredoxin 6; Peroxiredoxin-6; Prdx6; Thiol-specific antioxidant protein; Tsa
Gene Symbols: Prdx6
Molecular weight: 24,819 Da
Basal Isoelectric point: 5.64  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene