RAPH1 Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion. Belongs to the MRL family. Isoform RMO1-RAPH1 is ubiquitously expressed with highest levels in brain, heart, ovary and developing embryo. Isoform RMO1 is widely expressed with highest levels in liver. Low expression in B-cells. 9 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2q33.2
Cellular Component:  cytoskeleton; cytosol; filopodium; lamellipodium; nuclear body; plasma membrane
Molecular Function:  protein binding
Biological Process:  axon extension; signal transduction
Reference #:  Q70E73 (UniProtKB)
Alt. Names/Synonyms: ALS2CR18; ALS2CR9; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 18; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 9; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein; KIAA1681; Lamellipodin; LPD; PREL-2; PREL2; proline rich EVH1 ligand 2; Proline-rich EVH1 ligand 2; Protein RMO1; RalGDS/AF-6; RAPH1; Ras association (RalGDS/AF-6) and pleckstrin homology domains 1; Ras-associated and pleckstrin homology domains-containing protein 1; RMO1
Gene Symbols: RAPH1
Molecular weight: 135,256 Da
Basal Isoelectric point: 8.97  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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RAPH1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein