quiescin Q6 Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. Plays a role in disulfide bond formation in a variety of extracellular proteins. In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration. Belongs to the quiescin-sulfhydryl oxidase (QSOX) family. Expressed in heart, placenta, lung, liver, skeletal muscle, pancreas and very weakly in brain and kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Membrane protein, integral; Oxidoreductase
Chromosomal Location of human Ortholog: 1q25.2
Cellular Component:  endoplasmic reticulum lumen; extracellular exosome; extracellular region; extracellular space; Golgi apparatus; Golgi membrane; integral component of Golgi membrane; intercellular bridge; intracellular membrane-bounded organelle; platelet alpha granule lumen; specific granule lumen; tertiary granule lumen
Molecular Function:  FAD binding; flavin-linked sulfhydryl oxidase activity; protein disulfide isomerase activity
Biological Process:  cell redox homeostasis; cellular protein metabolic process; extracellular matrix assembly; negative regulation of macroautophagy; neutrophil degranulation; oxidation-reduction process; platelet degranulation; post-translational protein modification
Reference #:  O00391 (UniProtKB)
Alt. Names/Synonyms: FLJ34858; hQSOX; Q6; QSCN6; QSOX1; Quiescin Q6; quiescin Q6 sulfhydryl oxidase 1; quiescin sulfhydryl oxidase 1; Sulfhydryl oxidase 1; testis tissue sperm-binding protein Li 62n; thiol oxidase 1
Gene Symbols: QSOX1
Molecular weight: 82,578 Da
Basal Isoelectric point: 9.13  Predict pI for various phosphorylation states
Select Structure to View Below

quiescin Q6

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein