PKCH Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis. Promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Phosphorylates ATF2 which promotes its nuclear retention and transcriptional activity and negatively regulates its mitochondrial localization. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. Most abundant in lung, less in heart and skin. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: AGC group; EC 2.7.11.13; Eta subfamily; Kinase, protein; PKC family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 14q23.1
Cellular Component:  cytoplasm; cytosol; plasma membrane
Molecular Function:  ATP binding; enzyme binding; metal ion binding; protein binding; protein kinase C activity
Biological Process:  negative regulation of glial cell apoptotic process; platelet activation; positive regulation of B cell receptor signaling pathway; positive regulation of glial cell proliferation; positive regulation of keratinocyte differentiation; positive regulation of macrophage derived foam cell differentiation; positive regulation of NF-kappaB transcription factor activity; positive regulation of protein localization to plasma membrane; protein phosphorylation; regulation of bicellular tight junction assembly; signal transduction
Disease: Stroke, Ischemic
Reference #:  P24723 (UniProtKB)
Alt. Names/Synonyms: KPCL; MGC26269; MGC5363; nPKC-eta; PKC-L; PKCL; PRKCH; PRKCL; Protein kinase C eta type; protein kinase C, eta
Gene Symbols: PRKCH
Molecular weight: 77,828 Da
Basal Isoelectric point: 7.94  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis  |  Phospholipase Signaling
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PKCH

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