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PHF12
Acts as a transcriptional repressor. Involved in recruitment of functional SIN3A complexes to DNA. Represses transcription at least in part through the activity of an associated histone deacetylase (HDAC). May also repress transcription in a SIN3A-independent manner through recruitment of functional TLE5 complexes to DNA. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Chromosomal Location of human Ortholog: 17q11.2 |
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Cellular Component:
nucleoplasm; nucleus; Sin3 complex; Sin3-type complex; transcription repressor complex
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Molecular Function:
metal ion binding; phosphatidylinositol binding; protein binding; transcription corepressor activity; transcription corepressor binding
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Biological Process:
negative regulation of DNA-templated transcription; negative regulation of transcription by RNA polymerase II
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Reference #:
Q96QT6
(UniProtKB)
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Alt. Names/Synonyms: FLJ34122; KIAA1523; MGC131914; Pf1; PHD factor 1; PHD finger protein 12; PHD zinc finger transcription factor; PHF12
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Gene Symbols: PHF12
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Molecular weight:
109,698 Da
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Basal Isoelectric point:
7.94
Predict pI for various phosphorylation states
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