PHF12 Acts as a transcriptional repressor. Involved in recruitment of functional SIN3A complexes to DNA. Represses transcription at least in part through the activity of an associated histone deacetylase (HDAC). May also repress transcription in a SIN3A-independent manner through recruitment of functional TLE5 complexes to DNA. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Chromosomal Location of human Ortholog: 17q11.2
Cellular Component:  nucleoplasm; nucleus; Sin3 complex; transcriptional repressor complex
Molecular Function:  metal ion binding; phosphatidylinositol binding; protein binding; transcription corepressor activity; transcription corepressor binding
Biological Process:  negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated
Reference #:  Q96QT6 (UniProtKB)
Alt. Names/Synonyms: FLJ34122; KIAA1523; MGC131914; Pf1; PHD factor 1; PHD finger protein 12; PHD zinc finger transcription factor; PHF12
Gene Symbols: PHF12
Molecular weight: 109,698 Da
Basal Isoelectric point: 7.94  Predict pI for various phosphorylation states
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PHF12

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein