PARG
Poly(ADP-ribose) glycohydrolase that degrades poly(ADP-ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP-ribose). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers. It is however unable to cleave the ester bond between the terminal ADP-ribose and ADP-ribosylated residues, leaving proteins that are mono-ADP-ribosylated. Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG. Required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress, while it is not required for recovery from transient replicative stress. Required for retinoid acid-dependent gene transactivation, probably by removing poly(ADP-ribose) from histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters. Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming. Belongs to the poly(ADP-ribose) glycohydrolase family. Ubiquitously expressed. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: EC 3.2.1.143; Hydrolase |
Chromosomal Location of human Ortholog: 10q11.23 |
Cellular Component:
cytoplasm; cytosol; intracellular membrane-bounded organelle; mitochondrial matrix; nucleoplasm; nucleus
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Molecular Function:
poly(ADP-ribose) glycohydrolase activity; protein binding
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Biological Process:
ATP generation from poly-ADP-D-ribose; base-excision repair, gap-filling; carbohydrate metabolic process; nucleotide-sugar metabolic process; regulation of DNA repair
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Reference #:
Q86W56
(UniProtKB)
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Alt. Names/Synonyms: FLJ60456; mitochondrial poly(ADP-ribose) glycohydrolase; PARG; PARG99; poly (ADP-ribose) glycohydrolase; Poly(ADP-ribose) glycohydrolase; poly(ADP-ribose) glycohydrolase 60 kDa isoform
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Gene Symbols: PARG
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Molecular weight:
111,110 Da
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Basal Isoelectric point:
6.03
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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