PACS-1 Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin- coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Belongs to the PACS family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 11q13.1-q13.2
Cellular Component:  COPI-coated vesicle; cytosol; Golgi apparatus
Molecular Function:  ion channel binding; protein binding
Biological Process:  protein localization to Golgi apparatus; protein localization to plasma membrane; regulation of defense response to virus by virus
Disease: Mental Retardation, Autosomal Dominant 17
Reference #:  Q6VY07 (UniProtKB)
Alt. Names/Synonyms: cytosolic sorting protein PACS-1; FLJ10209; KIAA1175; PACS-1; PACS1; Phosphofurin acidic cluster sorting protein 1
Gene Symbols: PACS1
Molecular weight: 104,898 Da
Basal Isoelectric point: 7.6  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene