CNOT4 Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins. Involved in activation of the JAK/STAT pathway. Catalyzes ubiquitination of methylated RBM15. 9 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; EC; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 7q33
Cellular Component:  cytosol; nucleus
Molecular Function:  metal ion binding; protein binding; ubiquitin-protein transferase activity
Biological Process:  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; nuclear-transcribed mRNA poly(A) tail shortening; protein autoubiquitination; regulation of megakaryocyte differentiation; ubiquitin-dependent protein catabolic process
Reference #:  O95628 (UniProtKB)
Alt. Names/Synonyms: CCR4-associated factor 4; CCR4-NOT transcription complex subunit 4; CCR4-NOT transcription complex, subunit 4; CLONE243; CNOT4; E3 ubiquitin-protein ligase CNOT4; NOT4; NOT4 (negative regulator of transcription 4, yeast) homolog; NOT4H; Potential transcriptional repressor NOT4Hp; RING-type E3 ubiquitin transferase CNOT4
Gene Symbols: CNOT4
Molecular weight: 63,510 Da
Basal Isoelectric point: 6.58  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein