CNOT4 Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins. Involved in activation of the JAK/STAT pathway. Catalyzes ubiquitination of methylated RBM15. 9 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 7q33
Cellular Component:  cytosol; nucleus
Molecular Function:  metal ion binding; protein binding; ubiquitin-protein transferase activity
Biological Process:  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; nuclear-transcribed mRNA poly(A) tail shortening; protein autoubiquitination; regulation of megakaryocyte differentiation; ubiquitin-dependent protein catabolic process
Reference #:  O95628 (UniProtKB)
Alt. Names/Synonyms: CCR4-associated factor 4; CCR4-NOT transcription complex subunit 4; CCR4-NOT transcription complex, subunit 4; CLONE243; CNOT4; E3 ubiquitin-protein ligase CNOT4; NOT4; NOT4 (negative regulator of transcription 4, yeast) homolog; NOT4H; Potential transcriptional repressor NOT4Hp; RING-type E3 ubiquitin transferase CNOT4
Gene Symbols: CNOT4
Molecular weight: 63,510 Da
Basal Isoelectric point: 6.58  Predict pI for various phosphorylation states
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CNOT4

Protein Structure Not Found.


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