|
CNOT4
Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins. Involved in activation of the JAK/STAT pathway. Catalyzes ubiquitination of methylated RBM15. 9 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase |
| Chromosomal Location of Human Ortholog: 7q33 |
|
Cellular Component:
cytosol; nucleus
|
|
Molecular Function:
metal ion binding; protein binding; ubiquitin-protein transferase activity
|
|
Biological Process:
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; nuclear-transcribed mRNA poly(A) tail shortening; protein autoubiquitination; regulation of megakaryocyte differentiation; ubiquitin-dependent protein catabolic process
|
|
Reference #:
O95628
(UniProtKB)
|
|
Alt. Names/Synonyms: CCR4-associated factor 4; CCR4-NOT transcription complex subunit 4; CCR4-NOT transcription complex, subunit 4; CLONE243; CNOT4; E3 ubiquitin-protein ligase CNOT4; NOT4; NOT4 (negative regulator of transcription 4, yeast) homolog; NOT4H; Potential transcriptional repressor NOT4Hp; RING-type E3 ubiquitin transferase CNOT4
|
|
Gene Symbols: CNOT4
|
|
Molecular weight:
63,510 Da
|
|
Basal Isoelectric point:
6.58
Predict pI for various phosphorylation states
|
