Nna1 Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. Belongs to the peptidase M14 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.17.-; Protease
Chromosomal Location of Human Ortholog: 9q21.33
Cellular Component:  cytoplasm; cytosol; intracellular membrane-bounded organelle; mitochondrion; nucleolus; nucleus
Molecular Function:  metallocarboxypeptidase activity; tubulin binding; zinc ion binding
Biological Process:  C-terminal protein deglutamylation; cerebellar Purkinje cell differentiation; eye photoreceptor cell differentiation; mitochondrion organization; neuromuscular process; olfactory bulb development; protein side chain deglutamylation; proteolysis
Disease: Neurodegeneration, Childhood-onset, With Cerebellar Atrophy
Reference #:  Q9UPW5 (UniProtKB)
Alt. Names/Synonyms: AGTPBP1; ATP/GTP binding protein 1; ATP/GTP-binding protein 1; carboxypeptidase-tubulin; CBPC1; CCP1; CONDCA; Cytosolic carboxypeptidase 1; DKFZp686M20191; KIAA1035; Nervous system nuclear protein induced by axotomy; Nervous system nuclear protein induced by axotomy protein 1 homolog; NNA1; soluble carboxypeptidase; tubulinyl-Tyr carboxypeptidase; tyrosine carboxypeptidase
Gene Symbols: AGTPBP1
Molecular weight: 138,448 Da
Basal Isoelectric point: 5.78  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Nna1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene