MYST4
Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Belongs to the MYST (SAS/MOZ) family. Ubiquitously expressed, with high levels in heart, pancreas, testis and ovary. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Acetyltransferase; EC 2.3.1.48 |
Chromosomal Location of human Ortholog: 10q22.2 |
Cellular Component:
MOZ/MORF histone acetyltransferase complex; nucleoplasm; nucleosome; nucleus
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Molecular Function:
DNA binding; histone acetyltransferase activity; histone H3K14 acetyltransferase activity; metal ion binding; peptide-lysine-N-acetyltransferase activity; protein binding; protein-containing complex binding; transcription coactivator activity; transcription coregulator activity
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Biological Process:
DNA-templated transcription; histone acetylation; negative regulation of DNA-templated transcription; nucleosome assembly; positive regulation of DNA-templated transcription; positive regulation of transcription by RNA polymerase II; regulation of developmental process; regulation of DNA-templated transcription; regulation of hemopoiesis
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Disease: Genitopatellar Syndrome; Ohdo Syndrome, Sbbys Variant
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Reference #:
Q8WYB5
(UniProtKB)
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Alt. Names/Synonyms: DKFZp313G1618; FLJ90335; GTPTS; Histone acetyltransferase KAT6B; Histone acetyltransferase MORF; Histone acetyltransferase MOZ2; Histone acetyltransferase MYST4; K(lysine) acetyltransferase 6B; KAT6B; KIAA0383; lysine acetyltransferase 6B; Monocytic leukemia zinc finger protein-related factor; MORF; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4; MOZ-related factor; MOZ2; MYST histone acetyltransferase (monocytic leukemia) 4; MYST-4; MYST4; qkf; querkopf; ZC2HC6B
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Gene Symbols: KAT6B
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Molecular weight:
231,378 Da
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Basal Isoelectric point:
5.68
Predict pI for various phosphorylation states
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