MYST4 Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Belongs to the MYST (SAS/MOZ) family. Ubiquitously expressed, with high levels in heart, pancreas, testis and ovary. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; EC
Chromosomal Location of human Ortholog: 10q22.2
Cellular Component:  MOZ/MORF histone acetyltransferase complex; nucleoplasm; nucleosome; nucleus
Molecular Function:  acetyltransferase activity; DNA binding; histone acetyltransferase activity; metal ion binding; protein binding; transcription factor binding
Biological Process:  cellular response to leukemia inhibitory factor; histone acetylation; histone H3 acetylation; histone H4 acetylation; negative regulation of transcription, DNA-templated; nucleosome assembly; positive regulation of transcription, DNA-templated; regulation of transcription, DNA-templated
Disease: Genitopatellar Syndrome; Ohdo Syndrome, Sbbys Variant
Reference #:  Q8WYB5 (UniProtKB)
Alt. Names/Synonyms: DKFZp313G1618; FLJ90335; GTPTS; Histone acetyltransferase KAT6B; Histone acetyltransferase MORF; Histone acetyltransferase MOZ2; Histone acetyltransferase MYST4; K(lysine) acetyltransferase 6B; KAT6B; KIAA0383; lysine acetyltransferase 6B; Monocytic leukemia zinc finger protein-related factor; MORF; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4; MOZ-related factor; MOZ2; MYST histone acetyltransferase (monocytic leukemia) 4; MYST-4; MYST4; qkf; querkopf; ZC2HC6B
Gene Symbols: KAT6B
Molecular weight: 231,378 Da
Basal Isoelectric point: 5.68  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene